TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization

One of the main problems that remain in implant industry is poor osseointegration due to bioinertness implants. In order promote bioactivity, calcium (Ca), phosphorus (P) and strontium (Sr) were incorporated into a TiO2 porous layer produced by micro-arc oxidation. Ca P as bioactive elements are already well reported literature, however, knowledge effect Sr still limited. present work, various amounts was evaluated morphology, chemical composition crystal structure oxide investigated. Furthermore, vitro studies carried out using human osteoblast-like cells. The formed showed triplex structure, where higher incorporation increased Ca/P ratio, amount rutile promoted formation SrTiO3 compound. Biological tests revealed lower concentrations did not compromise initial cell adhesion neither viability interestingly improved mineralization. However, concentration (and consequent rutile) induce collagen secretion but with compromised mineralization, possibly delayed mineralization process or induced precipitation deficient hydroxyapatite. Ca-P-TiO2 less seems be an ideal candidate for bone